Eddie Brock, now separated from the Venom Symbiote, had his cancer cured by Martin Li, the alter ego of the Supervillain  Mister Negative. Unbeknownst to Li, his healing powers fused with the remnants of the Symbiote in Eddie’s body and created a new mindless Symbiote now known as Anti-Venom.

Base Stats & Abilities

HealthAttackPI (Max Signature)
(Rank 3, Level 45)

Character Class: Science

Basic Abilities: Spectre, Disoriented, Decelerate, Fury

ANTI-VENOM’s Mechanics

Anti-Venom inflicts a selection of three Debuffs on the Opponent when reaching a Combo threshold. Once the Opponent has been Debuffed he can choose to consume the Debuffs and turn them into stacks of Fury with his Special 2, which increases his damage output substantially. It is possible to increase the amount of Debuffs Anti-Venom can inflict on the Opponent, which consequently increases the amount of stacks of Fury Anti-Venom can acquire. 


  • Mystic Unblockable Counter
    • Anti-Venom is able to reduce the Ability Accuracy of Unblockable from Mystic Champions up to 100%. 
  • Heal Inverse
    • The Spectre and Petrify Debuffs, together with his Signature Ability and the Despair Mastery, can reduce Heal effects to the point of inversion. 
  • Utility
    • Anti-Venom has an unlimited duration of Slow and Disoriented Debuffs. 


  • Clean and Purify
    • Champions that can cleanse or purify when attacking won’t have much to worry about. 
  • Combo Control
    • Champions that are able to control their Combo Meter may be able to avoid Anti-Venom Debuffs from triggering most of the time.

The following Stats and Abilities are based on a Rank 5, Level 65, 5-Star Champion


Always Active

  • Immunity to Incinerate and Poison.
  • During the Opponent’s Special Attacks Anti-Venom gains 40% Defensive Combat Rate per Debuff on the Opponent.

Developer’s Note: Anti-Venom can gain quite a bit of Power when blocking or receiving attacks, and thanks to his Signature Ability, he can do so while not losing too much health.

Genetic Memory

  • When the fight starts Anti-Venom inflicts an indefinite Klyntar Debuff. If this Debuff is removed by any means it comes back after 15 second(s).
  • If the Opponent is suffering from the Klyntar Debuff, for every 10 hits in the Combo Meter from either Champion, Anti-Venom inflicts the selected Genetic Memory Debuff from the list below. Max Genetic Memory Debuffs 4.
  • Spectre Debuff: Reduces the Opponent’s Regeneration Rate by 16.66%
  • Disorient: Reduces Defensive Ability Accuracy and Block Proficiency by 12.5%.
  • Decelerate: Lowers Evade and Unstoppable Ability Accuracy by 33%.
  • Second Medium Attack changes the selected Genetic Memory Debuff to the next Debuff in the list. Defenders have a 50% chance to change the selection when inflicting a Genetic Memory Debuff.

Developer’s Note: A key aspect of playing with Anti-Venom is knowing which Debuffs to stack first against certain Champions.

Klyntar Debuff

  • Klyntar Debuff reduces Physical Vulnerability by 525 and gains additional properties based on Anti-Venom’s Opponent.
  • #Spider-Verse Heroes: Reduce the Ability Accuracy of Evade effects by 100%.
  • Mystic Champions: Reduce the Ability Accuracy of Unblockable by 65%. At 30 hits in the Combo Meter from either Champion it increases to 100%.

Developer’s Note: This Debuff coupled with Decelerate is able to completely counter Mystic Champions that make use of Unblockable and Unstoppable. 

Heavy Attacks

  • Inflict a Stagger that lasts for 10 second(s). A Staggered Opponent has their next Buff Nullified. Max 2 Stacks.

Special Attacks

  • Personal Passives are paused during Specials.

Special 1 – Constituent Hammer

  • If not already active, gain an Accelerated Mutation Passive, causing Anti-Venom to inflict an additional Genetic Memory Debuff for 15 second(s). Triggering Accelerated Mutation also refreshes the Evolved Mutation Passive.
  • If Accelerated Mutation is active, all hits deal a burst of 884.4 Physical damage.
  • First hit inflicts a Petrify Debuff, reducing the potency of their Power Gain and Regeneration effects by 40% for 20 second(s).

Developer’s Note: A very important aspect of his kit is being able to use Special 1 to refresh Evolved Mutation Passive from Special 3. If you can keep this Passive refreshed, Anti-Venom damage increases by a lot. 

Special 2 – Constituent Spear

  • On activation consume all Genetic Memory Debuffs on the Opponent, granting a Fury Passive per Genetic Memory consumed, gaining 1658.25 Attack Rating for 25 second(s).

Developer’s Note: Timing the use of Special 2 can make a huge difference when it comes to his loop. You need to be able to time the activation in such a way that would allow Anti-Venom to loop back to Special 1 so he can refresh the Evolved Mutation Passive.

Special 3 – Purge

  • Inflict a Rupture Debuff, dealing 1547.7 Physical Damage over 15 second(s).
  • Gain a non-stacking Evolved Mutation Passive, increasing the max number of Genetic Memory Debuffs by 4 and increasing Fury potency and duration by 25% for 25 second(s). The max stack for an individual Debuff is 4.

Developer’s Note: In longer fights Special 3 plays a key role in his loop. It allows Anti-Venom to inflict more Debuffs and consequently gain more stacks of Fury. 

Signature Ability – Controlled Symbiosis

When Attacked

  • Anti-Venom gains a Passive Regeneration stack that recovers 65% of the Attack Damage taken from a non-Critical Hit over 20 seconds and is interrupted if the Klyntar Debuff is Purified.
  • Personal Debuff potency is increased by 10% for every 10 hits in the Combo Meter from either Champion. Non-personal Debuffs are increased by 5% for every 10 hits in the Combo Meter. Effect caps at 50 hits.

Developer’s Note: At 50 hits in the Combo Meter and with the Accelerated Mutation Passive active, Anti-Venom only needs one application of each Debuff to get most of its utility, since Accelerated Mutation inflicts 2 Debuffs each with 50% increased potency, which is the equivalent of 3 Debuffs at normal potency. 


  •  CLOSE FAMILY with Venom, Carnage
    • Anti-Venom: #Symbiote Opponents have the Ability Accuracy of their Buffs reduced by 50%.
    • Venom, Carnage:Regenerates 15% of max Health when knocking out #Spider-Verse Heroes.
    • Unique Synergy: Does not stack with duplicate synergies.
  • TIME TRAVELERS with Spider-Man 2099,Doctor Octopus
    • Anti-Venom: For the first 10 second(s) of the fight the Opponent cannot gain Buffs.
    • Spider-Man 2099: On the start of the fight, inflict a Wither Debuff on the Opponent, reducing Ability Power Rate by 125% for 15 second(s).
    • Doctor Octopus: When dealing damage per Breakthrough removed on a Heavy Attack, 25% chance per Breakthrough to inflict another burst of damage dealing Attack Rating in damage.
    • Unique Synergy: Does not stack with duplicate synergies.
  • MAYBE LATER with Agent Venom
    • Anti-Venom: Inflicting a Genetic Memory Debuff deals a burst of 40% of Modified Attack in Physical Damage.
    • Agent Venom: Gain 10% Power anytime a Debuff is purified.
    • Unique Synergy: Does not stack with duplicate synergies.
  • COUNTER MEASURES with Green Goblin
    • Anti-Venom: Klyntar and Genetic Memory Debuffs are not affected by Ability Accuracy reduction.
    • Green Goblin: Afterburner inflicts additional stacks of Incinerate Debuff equal to the amount of stacks of Madness.
    • Unique Synergy: Does not stack with duplicate synergies.
  • HEADACHE with Punisher
    • Anti-Venom: Against #Villains Fury effects gain 30% potency.
    • Punisher: Gain 30% Offensive Ability Accuracy against #Villains.
    • Unique Synergy: Does not stack with duplicate synergies.


  • Despair
    • Together with Spectre and Petrify, Anti-Venom can easily reverse the Opponent’s healing.
  • Inequity
    • Anti-Venom puts tons of Debuffs on the Opponent, making the most of this Mastery.